General information:
| Function | lipophosphoglycan biosynthetic protein (lpg2) (LPG2) |
| Gene type | Protein coding gene |
| Transcript location | chr.34:1391065-1393737|+ |
| Alternative SL | 1391243(21),1391283(3),1391124(2),1391343(1),1391340(1) |
| Alternative polyA site | Not found |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.34.T3120 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.34.3120 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0002578,GO:0015780,GO:0015784,GO:0032695,GO:0052553,GO:0005794,GO:0016021,GO:0005338,GO:0005458
Associated PubMed publications:
- Ilg T, Demar M, Harbecke D. 2001. Phosphoglycan repeat-deficient Leishmania mexicana parasites remain infectious to macrophages and mice. J Biol Chem 276: 4988-4997. [PUBMED]
- Ma D, Russell DG, Beverley SM, Turco SJ. 1997. Golgi GDP-mannose uptake requires Leishmania LPG2. A member of a eukaryotic family of putative nucleotide-sugar transporters. J Biol Chem 272: 3799-3805. [PUBMED]
- Gaur U, Showalter M, Hickerson S, Dalvi R, Turco SJ, Wilson ME, Beverley SM. 2009. Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts. Exp Parasitol 122: 182-191. [PUBMED]
- Svarovska A, Ant TH, Seblova V, Jecna L, Beverley SM, Volf P. 2010. Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors. PLoS neglected tropical diseases 4: e580. [PUBMED]