General information:
| Function | ascorbate peroxidase (APX) |
| Gene type | Protein coding gene |
| Transcript location | chr.34:22687-25848|+ |
| Alternative SL | 22729(1) |
| Alternative polyA site | 25742(1) |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.34.T0070 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.34.0070 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0006916,GO:0006979,GO:0030322,GO:0055074,GO:0055114,GO:0005783,GO:0031304,GO:0004129,GO:0004447,GO:0004601,GO:0008447,GO:0020037,GO:0006800
Associated PubMed publications:
- Adak S, Datta AK. 2005. Leishmania major encodes an unusual peroxidase that is a close homologue of plant ascorbate peroxidase: a novel role of the transmembrane domain. Biochem J 390: 465-474. [PUBMED]
- Mukherjee A, Boisvert S, Monte-Neto RL, Coelho AC, Raymond F, Mukhopadhyay R, Corbeil J, Ouellette M. 2013. Telomeric gene deletion and intrachromosomal amplification in antimony-resistant Leishmania. Mol Microbiol 88: 189-202. [PUBMED]
- Kumar A, Das S, Purkait B, Sardar AH, Ghosh AK, Dikhit MR, Abhishek K, Das P. 2014. Ascorbate peroxidase, a key molecule regulating amphotericin B resistance in clinical isolates of Leishmania donovani. Antimicrob Agents Chemother 58: 6172-6184. [PUBMED]
- Pal S, Dolai S, Yadav RK, Adak S. 2010. Ascorbate peroxidase from Leishmania major controls the virulence of infective stage of promastigotes by regulating oxidative stress. PLoS One 5: e11271. [PUBMED]