General information:
| Function | pteridine reductase 1 (PTR1) |
| Gene type | Protein coding gene |
| Transcript location | chr.23:101792-103236|+ |
| Alternative SL | 101796(12),101584(29) |
| Alternative polyA site | Not found |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.23.T0270 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.23.0270 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0004799,GO:0005488,GO:0047040,GO:0019889,GO:0034599
Associated PubMed publications:
- Suman SS, Equbal A, Zaidi A, Ansari MY, Singh KP, Singh K, Purkait B, Sahoo GC, Bimal S, Das P et al. 2016. Up-regulation of cytosolic tryparedoxin in Amp B resistant isolates of Leishmania donovani and its interaction with cytosolic tryparedoxin peroxidase. Biochimie 121: 312-325. [PUBMED]
- de Souza Moreira D, Ferreira RF, Murta SM. 2015. Molecular characterization and functional analysis of pteridine reductase in wild-type and antimony-resistant Leishmania lines. Exp Parasitol 160: 60-66. [PUBMED]
- Herrmann FC, Sivakumar N, Jose J, Costi MP, Pozzi C, Schmidt TJ. 2017. In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I. Molecules 22. [PUBMED]
- Bello AR, Nare B, Freedman D, Hardy L, Beverley SM. 1994. PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proc Natl Acad Sci U S A 91: 11442-11446. [PUBMED]