General information:
| Function | GDP-mannose pyrophosphorylase (GDPMP) |
| Gene type | Protein coding gene |
| Transcript location | chr.23:23241-27445|+ |
| Alternative SL | 23172(3),23338(3) |
| Alternative polyA site | 27250(1),27253(1) |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.23.T0110 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.23.0110 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0004475,GO:0009298,GO:0008928,GO:0016779,GO:0009058,GO:0070085,GO:0006486,GO:0005737
Associated PubMed publications:
- Carnielli JBT, de Andrade HM, Pires SF, Chapeaurouge AD, Perales J, Monti-Rocha R, Carvalho SF, Ribeiro LP, Dietze R, Figueiredo SG et al. 2014. Proteomic analysis of the soluble proteomes of miltefosine-sensitive and -resistant Leishmania infantum chagasi isolates obtained from Brazilian patients with different treatment outcomes. Journal of proteomics 108: 198-208. [PUBMED]
- Garami A, Ilg T. 2001. Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability. Embo J 20: 3657-3666. [PUBMED]
- Mao W, Daligaux P, Lazar N, Ha-Duong T, Cave C, van Tilbeurgh H, Loiseau PM, Pomel S. 2017. Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads. Sci Rep 7: 751. [PUBMED]