General information:
| Function | xanthine phosphoribosyltransferase (XRPT) |
| Gene type | Protein coding gene |
| Transcript location | chr.21:315842-318403|+ |
| Alternative SL | 315856(1) |
| Alternative polyA site | Not found |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.21.T0850 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.21.0850 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0020015,GO:0000310,GO:0004422,GO:0043101,GO:0009116
Associated PubMed publications:
- Jardim A, Bergeson SE, Shih S, Carter N, Lucas RW, Merlin G, Myler PJ, Stuart K, Ullman B. 1999. Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis. J Biol Chem 274: 34403-34410. [PUBMED]
- Boitz JM, Ullman B. 2006. A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani. J Biol Chem 281: 16084-16089. [PUBMED]
- Patel B, Patel D, Parmar K, Chauhan R, Singh DD, Pappachan A. 2018. L. donovani XPRT: Molecular characterization and evaluation of inhibitors. Biochim Biophys Acta 1866: 426-441. [PUBMED]