General information:
| Function | hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
| Gene type | Protein coding gene |
| Transcript location | chr.21:313281-315405|+ |
| Alternative SL | 313298(1),313423(1) |
| Alternative polyA site | 315047(1) |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.21.T0845 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.21.0845 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0020015,GO:0004422,GO:0006166,GO:0009116,GO:0005737,GO:0043101
Associated PubMed publications:
- Allen TE, Hwang HY, Jardim A, Olafson R, Ullman B. 1995. Cloning and expression of the hypoxanthine-guanine phosphoribosyltransferase from Leishmania donovani. Mol Biochem Parasitol 73: 133-143. [PUBMED]
- Monzani PS, Alfonzo JD, Simpson L, Oliva G, Thiemann OH. 2002. Cloning, characterization and preliminary crystallographic analysis of Leishmania hypoxanthine-guanine phosphoribosyltransferase. Biochim Biophys Acta 1598: 3-9. [PUBMED]
- Hwang HY, Gilberts T, Jardim A, Shih S, Ullman B. 1996. Creation of homozygous mutants of Leishmania donovani with single targeting constructs. J Biol Chem 271: 30840-30846. [PUBMED]
- Ullman B, Carter D. 1997. Molecular and biochemical studies on the hypoxanthine-guanine phosphoribosyltransferases of the pathogenic haemoflagellates. Int J Parasitol 27: 203-213. [PUBMED]
- Boitz JM, Ullman B. 2006. A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani. J Biol Chem 281: 16084-16089. [PUBMED]