General information:
| Function | gamma-glutamylcysteine synthetase; putative (GSH1) |
| Gene type | Protein coding gene |
| Transcript location | chr.18:729040-732064|+ |
| Alternative SL | 729059(1),729130(1) |
| Alternative polyA site | Not found |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.18.T1660 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.18.1660 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0019342,GO:0000302,GO:0004357,GO:0006750
Associated PubMed publications:
- Grondin K, Haimeur A, Mukhopadhyay R, Rosen BP, Ouellette M. 1997. Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae. Embo J 16: 3057-3065. [PUBMED]
- Mukherjee A, Roy G, Guimond C, Ouellette M. 2009. The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants. Mol Microbiol 74: 914-927. [PUBMED]
- Fonseca MS, Comini MA, Resende BV, Santi AM, Zoboli AP, Moreira DS, Murta SM. 2017. Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony. Exp Parasitol 175: 36-43. [PUBMED]
- Agnihotri P, Singh SP, Shakya AK, Pratap JV. 2016. Biochemical and biophysical characterization of Leishmania donovani gamma-glutamylcysteine synthetase. Biochem Biophys Rep 8: 127-138. [PUBMED]