General information:
| Function | tryparedoxin peroxidase (TRYP3) |
| Gene type | Protein coding gene |
| Transcript location | chr.15:460118-461656|- |
| Alternative SL | 459345(5),459338(1) |
| Alternative polyA site | 457928(1),457946(1),457958(2) |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.15.T1080 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.15.1080 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0055114,GO:0016491,GO:0016209,GO:0051920,GO:0045454
Associated PubMed publications:
- Flohe L, Budde H, Bruns K, Castro H, Clos J, Hofmann B, Kansal-Kalavar S, Krumme D, Menge U, Plank-Schumacher K et al. 2002. Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism. Arch Biochem Biophys 397: 324-335. [PUBMED]
- Wyllie S, Vickers TJ, Fairlamb AH. 2008. Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials. Antimicrob Agents Chemother 52: 1359-1365. [PUBMED]
- Brotherton MC, Bourassa S, Legare D, Poirier GG, Droit A, Ouellette M. 2014. Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum. Int J Parasitol Drugs Drug Resist 4: 126-132. [PUBMED]
- Andrade JM, Murta SM. 2014. Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum lines. Parasites & vectors 7: 406. [PUBMED]
- Andrade JM, Murta SM. 2014. Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum lines. Parasites & vectors 7: 406. [PUBMED]
- Andrade JM, Murta SM. 2014. Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum lines. Parasites & vectors 7: 406. [PUBMED]
- Carnielli JBT, de Andrade HM, Pires SF, Chapeaurouge AD, Perales J, Monti-Rocha R, Carvalho SF, Ribeiro LP, Dietze R, Figueiredo SG et al. 2014. Proteomic analysis of the soluble proteomes of miltefosine-sensitive and -resistant Leishmania infantum chagasi isolates obtained from Brazilian patients with different treatment outcomes. Journal of proteomics 108: 198-208. [PUBMED]
- Barr SD, Gedamu L. 2001. Cloning and characterization of three differentially expressed peroxidoxin genes from Leishmania chagasi. Evidence for an enzymatic detoxification of hydroxyl radicals. J Biol Chem 276: 34279-34287. [PUBMED]
- Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM. 2002. Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum. Free Radic Biol Med 33: 1552-1562. [PUBMED]
- Morais MAB, Giuseppe PO, Souza T, Castro H, Honorato RV, Oliveira PSL, Netto LES, Tomas AM, Murakami MT. 2017. Calcium and magnesium ions modulate the oligomeric state and function of mitochondrial 2-Cys peroxiredoxins in Leishmania parasites. J Biol Chem 292: 7023-7039. [PUBMED]