General information:
| Function | tryparedoxin peroxidase (TRYP2) |
| Gene type | Protein coding gene |
| Transcript location | chr.15:457262-458665|- |
| Alternative SL | 456354(3),456474(1),456330(1) |
| Alternative polyA site | Not found |
| Other features | - |
Sequence:
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Here you can download sequence data derived from our research.
- LmjF.15.T1060 transcript sequence: This sequence includes the coding sequence within uppercase letters.
- LmjF.15.1060 protein sequence: Aminoacidic sequence of the corresponding protein.
Based on the updated L.major genome (Alonso et al. 2016):
Associated GO terms:
- GO:0045454,GO:0055114,GO:0051920,GO:0016209,GO:0016491
Associated PubMed publications:
- Flohe L, Budde H, Bruns K, Castro H, Clos J, Hofmann B, Kansal-Kalavar S, Krumme D, Menge U, Plank-Schumacher K et al. 2002. Tryparedoxin peroxidase of Leishmania donovani: molecular cloning, heterologous expression, specificity, and catalytic mechanism. Arch Biochem Biophys 397: 324-335. [PUBMED]
- Wyllie S, Vickers TJ, Fairlamb AH. 2008. Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials. Antimicrob Agents Chemother 52: 1359-1365. [PUBMED]
- Brotherton MC, Bourassa S, Legare D, Poirier GG, Droit A, Ouellette M. 2014. Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum. Int J Parasitol Drugs Drug Resist 4: 126-132. [PUBMED]
- Andrade JM, Murta SM. 2014. Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum lines. Parasites & vectors 7: 406. [PUBMED]
- Barr SD, Gedamu L. 2001. Cloning and characterization of three differentially expressed peroxidoxin genes from Leishmania chagasi. Evidence for an enzymatic detoxification of hydroxyl radicals. J Biol Chem 276: 34279-34287. [PUBMED]